PERSPECTIVE
Immersion Day — Transforming Governance and Policy by Putting on Scrubs
The Science of Choosing Wisely — Overcoming the Therapeutic Illusion
Federal Research Regulations for the 21st Century
ORIGINAL ARTICLES
Randomized Trial of Longer-Term Therapy for Symptoms Attributed to Lyme Disease
Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol
Extended-Release Naltrexone to Prevent Opioid Relapse in Criminal Justice Offenders
Baricitinib in Patients with Refractory Rheumatoid Arthritis
REVIEW ARTICLE
Opioid Abuse in Chronic Pain — Misconceptions and Mitigation Strategies
IMAGES IN CLINICAL MEDICINE
Paget’s Disease of Bone
Carotid–Cavernous Sinus Fistula
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL
Case 10-2016 — A 22-Year-Old Man with Sickle Cell Disease, Headache, and Difficulty Speaking
EDITORIALS
Time for a Different Approach to Lyme Disease and Long-Term Symptoms
Postmenopausal Hormone Therapy and Atherosclerosis — Time Is of the Essence
SPECIAL REPORT
The Neglected Dimension of Global Security — A Framework for Countering Infectious-Disease Crises
CLINICAL IMPLICATIONS OF BASIC RESEARCH
Genetic Targeting of the Albumin Locus to Treat Hemophilia
CORRESPONDENCE
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection
Malignant Transformation of Hymenolepis nana in a Human Host
Thyroid Nodules
Nonmedical Prescription-Opioid Use and Heroin Use
Two Cases of Vaccine-Derived Poliovirus Infection in an Oncology Ward
CORRECTIONS
Effect of Removal of Planned Parenthood from the Texas Women's Health Program
Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care