# In This Issue of JAMA
Audio Highlights
# Original Investigation
RNA Interference With Zilebesiran for Mild to Moderate HypertensionThe KARDIA-1 Randomized Clinical Trial
George L. Bakris, MD; Manish Saxena, MBBS; Anil Gupta, MD; et al.
Endovascular Thrombectomy for Large Ischemic Stroke Across Ischemic Injury and Penumbra Profiles
Amrou Sarraj, MD; Ameer E. Hassan, DO; Michael G. Abraham, MD; et al.
Time to Treatment With Intravenous Thrombolysis Before Thrombectomy and Functional Outcomes in Acute Ischemic StrokeA Meta-Analysis
Johannes Kaesmacher, MD, PhD; Fabiano Cavalcante, MD; Manon Kappelhof, MD, PhD; et al.
# Research Letter
Delivery Device Patents on GLP-1 Receptor Agonists
Rasha Alhiary, PharmD, MS; Sarah Gabriele, LLM, MBE; Aaron S. Kesselheim, MD, JD, MPH; et al.
Trends in Phenylephrine and Pseudoephedrine Sales in the US
Timothy S. Anderson, MD, MAS; Katie J. Suda, PharmD, MS; Walid F. Gellad, MD, MPH; et al.
# Viewpoint
Maintenance of Certification—The Value to Patients and Physicians
Robert O. Roswell, MD; Erica N. Johnson, MD; Rajeev Jain, MD
Out of Touch
Salvatore Mangione, MD; Maria Basile, MD, MBA; Stephen G. Post, PhD
# A Piece of My Mind
I Am Your Father
Daniel A. Gorman, MD
# Editorial
RNA Injection Every 6 Months to Improve Adherence and Lower Blood Pressure in Patients With Hypertension
Ernesto L. Schiffrin, MD, PhD
Thrombectomy in Medium to Large Ischemic CoreDo Patients Still Need to Be SELECTed?
Umberto Pensato, MD; Ronda Lun, MD; Andrew Demchuk, MD
Communicating Medicine—A New JAMA Series
Anne R. Cappola, MD, ScM; Kirsten Bibbins-Domingo, PhD, MD, MAS
# Review
Cardiac Amyloidosis Due to Transthyretin ProteinA Review
Frederick L. Ruberg, MD; Mathew S. Maurer, MD
# JAMA Insights
Delivering Effective Messages in the Patient-Clinician Encounter
Joseph N. Cappella, PhD; Richard L. Street Jr, PhD
# Medical News & Perspectives
When It Comes to SARS-CoV-2 Clearance, People Who Are Immunocompromised Are Not All Alike
Rita Rubin, MA
# Medical News in Brief
E-Cigarettes May Be Better Than Nicotine Gum for Quitting Smoking
Emily Harris
Eating Keto, Vegan Diets Rewired Immune System Within 2 Weeks
Emily Harris
“Alarming Trend” Persists as Syphilis Cases Swelled in the US in 2022
Emily Harris
Weight Loss Surgery Managed Blood Pressure for People With Obesity
Emily Harris
Weaker Link Than Expected Between Exercise and Less Cognitive Decline
Emily Harris
Millions of US Children Experience Range of Long COVID Effects
Emily Harris
Low Levels of Protein Biomarker Could Predict Sepsis Deaths
Emily Harris
Primary Care Physicians Are Key to Improving Dementia Care and Access
Emily Harris
# Poetry and Medicine
Congenital Diaphragmatic Hernia
Sarah N. Cross, MD
# JAMA Revisited
Brain Work
# JAMA Patient Page
What Is Childhood Leukemia?
Jenny Ruiz, MD, MSCE; Colleen Mathews, MD; Erika Friehling, MD, MS
# Comment & Response
Treatment for Hyperthyroidism During Pregnancy
Virginia Y. Watkins, MD; Sarah K. Dotters-Katz, MD, MSHPEd; Jeffrey A. Kuller, MD
Treatment for Hyperthyroidism During Pregnancy—Reply
Elizabeth N. Pearce, MD, MSc; Sun Y. Lee, MD, MSc
Pharmacotherapy for Alcohol Use Disorder
Wenming Shi, PhD
Pharmacotherapy for Alcohol Use Disorder—Reply
Melissa McPheeters, PhD, MPH; Elizabeth A. O’Connor, PhD; Daniel E. Jonas, MD, MPH
Medical Student Intent to Practice in Underserved Areas
Kai Salas Akimoto, BA; Denise Taitano-Ritter, MD; Kekoa Taparra, MD, PhD
Medical Student Intent to Practice in Underserved Areas
Michael Soh, PhD
Medical Student Intent to Practice in Underserved Areas—Reply
Liselotte N. Dyrbye, MD, MHPE; Colin P. West, MD, PhD
# Correction
Incorrect Study Dates and Author Affiliation
# JAMA Masthead
JAMA